Ron H.N. van Schaik• Posted this - APRIL is Following on Linkedin.Full Professor Pharmacogenetics / Head Dept Clinical Chemistry / Past-President European Society Pharmacogenomics & Personalised Therapy (ESPT)
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5 days ago
Adverse drug reactions (ADRs) caused by everyday medicines, or anaesthetics can include depression, anxiety, insomnia, suicidal feelings. Pharmaceutical drugs for pain, infections, acne, anxiety, depression, may cause immediate or withdrawal reactions. Genetic differences may put individuals at risk Refer to our updated web site: www.april.org.uk for extensive information, Please follow us on Twitter @APRIL_charity APRIL (Adverse Psychiatric Reactions Information Link) www.april.org.uk
At last in March 2022 a promise for Personalised Medication Prescribing. This should dramatically reduce harm done to many by using medication they cannot tolerate, or does nothing to improve their condition.
A Detailed report just published March 2022 by the
Royal College of Physicians & British Pharmacological Society -
Click Here for the Report: PERSONALISED PRESCRIBING
An article in The Guardian Experts push for genetic testing to personalise drug prescriptions explains the benefits, as About 6.5% of UK hospital admissions are caused by adverse drug reactions, while most prescription medicines only work on 30% to 50% of people.
Click here for the Guardian article by Linda Geddes:
APRIL has been promoting the use of genetic testing for many years - Click here for a talk by Professor Sir Munir Pirmohamed, Chair of the Working Group on Personalised Prescribing, speaking at our conference
The aim of this web site is to share information about psychiatric adverse effects of prescribed medicines and anaesthetics.However many who suffer adverse reactions are then prescribed psychotropic drugs, some cause dependence.
Read below about an online conference on issues of dependence and withdrawal from antidepressants, benzodiasepines and other drugs causing serious withdrawal reactions. With Professor Joanna Moncrieff and Robert Whitaker
Re the MHRA Isotretinoin expert working Group (IEWG) conclusions following submission of evidence from Millie Kieve for APRIL charity, together with many parents tragically bereaved by the suicide of their child.
The outcome of our written and face to face (via Zoom) submissions of evidence, is very slow to emerge and more will be posted about this at a later date.
For my part (Millie) - News of the work for APRIL which is ongoing, even though my age tells me to slow down!
I have now given up the office as I had rarely been into the space since the Covid lockdown, so am working on books about the history of APRIL and my life in fact!
In the meantime I have updated some videos on the Vimeo web site and this one is the newest:
It is a talk that started as a conversation between me and my long time volunteer and friend Kathy.
I decided as I was explaining some of the history of the efforts I have made to help towards greater patient safety, I may as well record this. So I added still pictures to help illustrate the information. This covers the early years around the time of the first conference I organised.
This includes when Dr David Healy (now Professor) was rejected after having his post as Professor in Toronto, following his talk to a few doctors, I believe, about the risk of suicide for some people taking antidepressant SSRI and similar drugs. You will hear he did agree to speak at that first conference, which led to the amazing work by the BBC Panorama team in highlighting the issues around dependence and harm caused by the SSRI antidepressant Seroxat.
The fact that dosage was licensed too high and how the CEO of MIND charity actually resigned from and committee of people working for the Medicines regulator at the time, for reasons of failure to disclose or act on harm they knew about.
Please listen to the 11 minute 'conversation' in which I do actually include Kath's contribution, but not all as it may have been unsuitable for sharing!
There are many videos of interest I have edited and included on Vimeo and the link to them all is on the Home Page of APRIL's web site https://www.april.org.uk Talks by leading experts in adverse drug reactions (ADRs) and how clinical trials have been rigged in favour of benefits from medicines with cover up of harms. Testimonials of suffering and recovery from people who have been sectioned for psychiatric issues, some due to the ADRs they suffered.
I will do more on the blog if I can be sure some people are still reading my posts. Please enter your email to be informed of new posts. I have no access to that data so have no idea how many of you may have signed up.
Kind regards to all and stay safe from Covid - with heartfelt concern for those in Ukraine who have far more than Covid to worry about.
Isotretinoin / Roaccutane / Reticutan / Rizuderm / Accutane
Please submit your views for an Expert Review of your experience or your relative or friend's as to the safety or otherwise of this acne medication.
Closing date for submission extend to 16th February 2021
UK and non UK submissions welcome
Concerns about suicide, depression and physical harm linked to using this acne medication are worldwide.
EU ADR database records psychiatric Adverse Drug Reactions (ADRs) 30,295 with reported cases of completed suicide by people using the acne drug 440 by 01/02/21
The original manufacturer Roche withdrew the drug from the US market following extensive amount of litigation. The US litigation was also about the drug causing Inflammatory Bowel Disease such as Ulcerative Colitis.
Only licensed for for severe acne, yet has been given to people with mild acne. One young medical student with a few spots on his back died by suicide - you can hear his father's account here: https://vimeo.com/16759077
Roaccutane / isotretinoin and generic versions can cause serious adverse reactions for some people .
Please submit your views for the Expert Review due to concerns about suicide, depression and physical harm linked to usage - date has been extended until February 16 2021.
Worldwide - not just the UK - so please if you have any views, if you or a family member has concerns about adverse effects you may not expect, such as on libido or mood changes or if you were bereaved suddenly and the victim was using or had stopped using the acne drug, please access via the link below and submit your views by Feb 16 2021
Great move forward!
There are also plans to expand pharmacogenomic testing in Scotland, where health board NHS Tayside has begun a routine clopidogrel genotype testing service in secondary care after acute stroke, and there are also plans in development to use pharmacogenomic testing pilots more broadly using gene panels.
#pharmacogenetics #CYP2D6 #CYP2C19 #SLCO1B1
Joba van den Berg Ernst Kuipers