Wednesday, 4 January 2023


First-ever NHS pilot of routine pharmacogenetic testing to guide drug choice in primary care will begin in early 2023 in north-west England, with plans for it to become a national programme if successful. Drugs include antidepressants, statins and proton pump inhibitors (PPIs).

Great move forward!

There are also plans to expand pharmacogenomic testing in Scotland, where health board NHS Tayside has begun a routine clopidogrel genotype testing service in secondary care after acute stroke, and there are also plans in development to use pharmacogenomic testing pilots more broadly using gene panels.

#pharmacogenetics #CYP2D6 #CYP2C19 #SLCO1B1
Joba van den Berg Ernst Kuipers

Sunday, 10 April 2022

Personalised Medicine promise - to prevent high rate of adverse drug reactions (ADRs)



Personalised Medicine 

 At last in March 2022 a promise for Personalised Medication Prescribing. This should dramatically reduce harm done to many by using medication they cannot tolerate, or does nothing to improve their condition.

A Detailed report just published March 2022 by the 
Royal College of Physicians & British Pharmacological Society -


An article in The Guardian Experts push for genetic testing to personalise drug prescriptions explains the benefits, as About 6.5% of UK hospital admissions are caused by adverse drug reactionswhile most prescription medicines only work on 30% to 50% of people.
Click here for the Guardian article by Linda Geddes:

APRIL has been promoting the use of genetic testing for many years  - Click here for a talk by Professor Sir Munir Pirmohamed, Chair of the Working Group on Personalised Prescribing, speaking at our conference

The aim of this web site is to share information about psychiatric adverse effects of prescribed medicines and anaesthetics.However many who suffer adverse reactions are then prescribed psychotropic drugs, some cause dependence.

Read below about an online conference on issues of dependence and withdrawal from antidepressants, benzodiasepines and other drugs causing serious withdrawal reactions. With Professor Joanna Moncrieff and Robert Whitaker

Withdrawal from Medication
CONFERENCE - May 6/7 2022  
Click for flyer: 
Withdrawal from Psychiatric Drugs

Thursday, 3 March 2022

The MHRA Roaccutane / isotretinoin Inquiry into harms some people suffer, is still ongoing. Plus link to Millie Kieve's newest video.

 Re the MHRA Isotretinoin expert working Group (IEWG) conclusions following  submission of evidence from Millie Kieve for APRIL charity, together with many parents tragically bereaved by the suicide of their child.

The outcome  of our written and face to face (via Zoom) submissions of evidence, is very slow to emerge and more will be posted about this at a later date.

For my part (Millie)  - News of the work for APRIL which is ongoing, even though my age tells me to slow down!

I have now given up the office as I had rarely been into the space since the Covid lockdown, so am working on books about the history of APRIL and my life in fact!

In the meantime I have updated some videos on the Vimeo web site and this one is the newest:

It is a talk that started as a conversation between me and my long time volunteer and friend Kathy.

I decided as I was explaining some of the history of the efforts I have made to help towards greater patient safety, I may as well record this. So I added still pictures to help illustrate the information. This covers the early years around the time of the  first conference I organised.

This includes when Dr David Healy (now Professor) was rejected after having his post as Professor in Toronto, following his talk to a few doctors, I believe, about the risk of suicide for some people taking antidepressant SSRI and similar drugs. You will hear he did agree to speak at that first conference, which led to the amazing work by the BBC Panorama team in highlighting the issues around dependence and harm caused by the SSRI antidepressant Seroxat. 

The fact that dosage was licensed too high and how the CEO of MIND charity actually resigned from and committee of people working for the Medicines regulator at the time, for reasons of failure to disclose or act on harm they knew about.

Please listen to the 11 minute 'conversation' in which I do actually include Kath's contribution, but not all as it may have been unsuitable for sharing! 

There are many videos of interest I have edited and included on Vimeo and the link to them all is on the Home Page of APRIL's web site Talks by leading experts in adverse drug reactions (ADRs) and how clinical trials have been rigged in favour of benefits from medicines with cover up of harms. Testimonials of suffering and recovery from people who have been sectioned for psychiatric issues, some due to the ADRs they suffered.

I will do more on the blog if I can be sure some people are still reading my posts. Please enter your email to be informed of new posts. I have no access to that data so have no idea how many of you may have signed up.

Kind regards to all and stay safe from Covid - with heartfelt concern for those in Ukraine who have far more  than Covid to worry about.

Wednesday, 3 February 2021

Inquiry invites your views as concern about psychiatric and physical harm from acne drug isotretinoin / Ro - Accutane / Reticutan / Rizuderm

 Isotretinoin / Roaccutane / Reticutan / Rizuderm / Accutane 

Please submit your views for an Expert Review of your experience or your relative or friend's as to the safety or otherwise of this acne medication. 

Closing date for submission extend to 16th February 2021 

UK and non UK submissions welcome

Concerns about suicide, depression and physical harm linked to using this acne medication are worldwide. 

EU ADR database records psychiatric Adverse Drug Reactions (ADRs) 30,295 with reported cases of completed suicide by people using the acne drug 440 by 01/02/21

The original manufacturer Roche withdrew the drug from the US market following extensive amount of litigation. The US litigation was also about the drug causing Inflammatory Bowel Disease such as Ulcerative Colitis.

Only licensed for for severe acne, yet has been given to people with mild acne. One young medical student with a few spots on his back died by suicide - you can hear his father's account here: 

 Roaccutane / isotretinoin and generic versions can cause serious adverse reactions for some people . 

Please submit your views for the Expert Review due to concerns about suicide, depression and physical harm linked to usage - date has been extended until February 16 2021.

Worldwide - not just the UK - so please if you have any views, if you or a family member has concerns about adverse effects you may not expect, such as on libido or mood changes  or  if you were bereaved suddenly and the victim was using or had stopped using the acne drug, please access via the link below and submit your views by Feb 16 2021 

Monday, 29 June 2020

Benzo Belle is about preventing Harm from Medicines by Calista Cazuko

Calista Cazuko is a remarkable young and lovely singer songwriter. 
Her first meeting with me (Millie) was when I was thinking of having piano lessons and
we both lived near a piano shop.

So from music we got on to the subject of medicines, in particular Dianette.
Hear what Calista says about the years (contrary to the licensing) she took this acne drug as a contraceptive pill.

The blog post is so delightful to listen to and has some very good advice both from Calista and from her 
guest Melanie Davis. Melanie use to work with MIND and she talks about her project to help people with their benzodiazepine issues, either to reduce or withdraw. 

Many support activities involving music were set up for the victims of Benzo addiction. Many were unaware the drugs cause dependence.

So please listen to the latest blog  "Benzo Belle"and there are links on the page too. This is part of the Empress Diaries project.

Analysis of FDA Antidepressant suicide risk in RCTrials

New Generation_Antidepressants_and_Suicide_Risk_in_Randomized_Controlled_Trials_A_Re-Analysis_of_the_FDA_Databaseer-

The full paper is available from the link

Or google as it is freely available.

Wednesday, 12 June 2019

Antidepressants withdrawal effects


May 2019

 The UK Royal College of Psychiatrists have finally agreed, after years of denial.
Withdrawal from antidepressants and benzodiazepine drugs at last being recognised as sometimes causing serious adverse effects  harming many people.

National clinical guidelines are currently being updated.

Wendy Burn, president of the Royal College of Psychiatrists, said she wanted to see the guidelines "more in keeping with what we're hearing from some patients - and GPs - about the range of experiences of coming off antidepressants".

The number of prescriptions for antidepressants in the UK nearly doubled between 2007 and 2017, from around 40 million to more than 82 million, a report by the College shows.

The Royal College of Psychiatrists now accepts that it has not paid enough attention to patients suffering from severe withdrawal symptoms when coming off antidepressants.

The new stance by the Royal College follows a Lancet Psychiatry paper co-authored by David Taylor, the director of pharmacy and pathology at the Maudsley Hospital in London, who has himself experienced withdrawal, describing it in a recent New Yorker article as a “strange and frightening and torturous” experience that lasted six weeks. “Although the withdrawal syndrome can be differentiated from recurrence of the underlying disorder, it might also be mistaken for recurrence, leading to long-term unnecessary medication,” reads the paper.

 Despite current guidelines recommending a taper of two to four weeks, “tapers over a period of months and down to doses much lower than minimum therapeutic doses have shown greater success in reducing withdrawal symptoms”.

Back in 2014 APRIL_charity was contacted by a desperate relative, trying to convince the psychiatrists it was withdrawal causing the problems. The psychiatrists only wanted to prescribe more and more medication.
They told us:
“I was saying that it was a result of withdrawal in the end it slightly registered but they will only treat on the basis of diagnosis and relapse and it's always more medication. I think you're right it is the way they are trained. You're website is really helpful and a gem to find when such information is so valuable and rare. Thanks once again for taking the time out of your busy day and I will continue to visit your site and support where I can.”

In 2018 the headline in the British Medical Journal was:

Government must investigate rising excess deaths in England and Wales, experts warn

BMJ 2018; 361 doi: (Published 11 May 2018) Cite this as: BMJ 2018;361:k2127
Research experts have urged the government and MPs to investigate rising numbers of deaths in England and Wales, after new figures showed over 20 000 “excess deaths” so far in 2018.
Earlier this year an analysis of the Office for National Statistics’ data on weekly provisional deaths in England and Wales, published in The BMJ,1 found that by week seven of 2018 (ending 16 February) 10 000 more people had died than the average from the past five years.